Scientific Sessions

EMBO Plenary Lecture

Chair: Heidi McBride

Gottfried Schatz (Basel, Switzerland)

What it takes to succeed in science

Mitochondrial dynamics

Chair: Heidi McBride

Jodi Nunnari (Davis, CA, USA)

Mitochondrial Dynamics

Janet M. Shaw (Salt Lake City, UT, USA)

Identification of the minimal mitochondrial fission machinery in yeast and humans

Dinner

Breakfast

Motility and positioning

Chair: Hans Spelbrink

Tom Schwarz (Boston, MA, USA)

Regulating how mitochondria stop and go

Nobuhiko Ohno (Cleveland, OH, USA)

Modulation of mitochondrial motility and distribution in demyelinated axons

Josef Kittler (London, UK)

Regulation of mitochondrial trafficking and neuronal function by Miro family proteins

Gyorgy Hajnóczky (Philadelphia, PA, USA)

Mitochondrial calcium signaling

Coffee break

Mitochondrial fusion

Chair: Hsiuchen Chen

David Chan (Pasadena, CA, USA)

Physiological functions of mitochondrial dynamics in mammals

Andreas Reichert (Frankfurt, Germany)

Molecular insights into cristae formation

Mickael Cohen (Paris, France)

The ubiquitin-proteasome system is integral to fusion of mitochondrial outer membranes

Albert Neutzner (Basel, Switzerland)

The ubiquitin ligase RTM9 is a regulator of mitochondrial fusion and involved in mitochondrial maintenance

Guy Lenaers (Montpellier, France)

Implication of OPA1 in the quantitative and qualitative maintenance of the mitochondrial genome. Pathological relevancies

Lunch and free time

High Throughput Approaches and Systems Biology

Chair: Giorgio Casari

David Andrews (Hamilton, Canada)

Interactions with mitochondrial membranes regulate Bcl-2 family protein:protein interactions with life and death consequences

Carla Koehler (Los Angeles, CA, USA)

Small molecule modulators for mitochondrial protein translocation

Robert Screaton (Ottawa, Canada)

Functional genomic screening identifies novel regulators of mitochondrial dynamics

Till Klecker (Bayreuth, Germany)

Mapping of the genetic interactome of yeast MDM33 by a novel microarray-based genome wide screen

Poster Session 1:
Mitochondrial Dynamics

Mitochondrial fission

Chair: Blake Hill

Alexander van der Bliek (Los Angeles, CA, USA)

Mitochondrial fission and fusion in mammalian cells and in C. elegans

Katsuyoshi Mihara (Fukuoka, Japan)

Drp1-dependent mitochondrial fission in mammalian cells

Thierry Touvier (Bosisio Parini, Italy)

Role of DRP-1 in myogenesis and muscle regeneration

Michael Ryan (Melbourne, Australia)

MiD49 and MiD51, new regulators of mitochondrial fission

Dinner

Breakfast

Mitochondrial quality control

Chair: Luca Pellegrini

Thomas Langer (Cologne, Germany)

Proteolytic control of mitochondrial membrane dynamics

Jared Rutter (Salt Lake City, UT, USA)

Adding a face to the name: meeting the mitochondrial proteome

Edward Fon (Montreal, Canada)

The mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment

Koji Okamoto (Okazaki, Japan)

Molecular mechanism of mitophagy in yeast

Coffee break

Lipid signaling and ER contacts

Chair: Jodi Nunnari

Alessandra d'Azzo (Memphis, TN, USA)

Accumulation of GM1-ganglioside in inter-organellar membrane microdomains results in Ca²⁺-mediated neurodegeneration

Ji Zhang (La Jolla, CA, USA)

Substrate identification of a mitochondrial “Protein” phosphatase: an unexpected role in cardiolipin biosynthesis

Jose Carlos Fernandez-Checa (Barcelona, Spain)

Mitochondrial cholesterol in health and disease

Thomas Simmen (Edmonton, Alberta, Canada)

Chaperones and oxidoreductases of the mitochondria-associated membrane (MAM)

Lunch and free time

Emerging topics

Chair: Richard Youle

Mariusz Karbowski (Baltimore, MD, USA)

Regulation of outer mitochondrial membrane protein turnover and mitochondria-specific autophagy by ubiquitin/proteasome system and AAA-ATPase, p97

Kasturi Mitra (Bethesda, MD, USA)

Mitochondrial fission-fusion controls cell proliferation and entry into differentiation

Konstanze Winklhofer (Munich, Germany)

Separate pathways are implicated in the stress-protective and mitophagy-inducing activity of parkin

Fabrizia Stavru (Paris, France)

Mitochondrial dynamics in Listeria monocytogenes infection

Poster Session 2:
Function, Biogenesis, and Quality Control

Seahorse Workshop

Chris Braun (North Billerica, MA, USA)

Mitochondria in aging: new technology for assessing mitochondrial dysfunction

Mitochondrial disease

Chair: Pascale Belenguer

Eric Shoubridge (Montreal, Canada)

New players in mitochondrial translation

Massimo Zeviani (Milan, Italy)

Mitochondrial disorders: from the discovery of new disease genes to the development of experimental treatments

Brendan Battersby (Helsinki, Finland)

Gimap3, a modifier of mtDNA segregation in leukocytes

Anu Suomalainen-Wartiovaara (Helsinki, Finland)

Consequences of mitochondrial dysfunction in stem cell compartment

Dinner

Breakfast

Apoptosis/Cancer

Chair: Stefan Frank

Gordon Shore (Montreal, Canada)

Targeting Mcl-1 for synthetic lethality in cancer therapy

Francesco Cecconi (Rome, Italy)

Mitochondria regulate the novel non-apoptotic roles of cell death-related molecules

Lorrie Allan Kirshenbaum (Winnipeg, Canada)

Preferential targeting of Bnip3 isoforms to mitochondria and endoplasmic reticulum during metabolic stress

Alexis Jourdain (Geneva, Switzerland)

Dual-targeting of the stress protein FASTK to cytosol and mitochondria

Rosario Rizzuto (Padua, Italy)

Molecular identification of the mitochondrial calcium uniporter

Coffee break

Immunology and mitochondrial function

Chair: Eleni Douni

Zhijian (James) Chen (Dallas, TX, USA)

MAVS – A Marvelous Mitochondrial Anti-Viral Signaling Protein

Olaf Gross (Lausanne, Switzerland)

The Riddle of Inflammasome Activation

Silvia Campello (Geneva, Switzerland)

Mitochondrial shape changes amplify physiological Activation-Induced Cell Death

Takumi Koshiba (Fukuoka, Japan)

Mitochondrial Membrane Potential is required for MAVS-Mediated Antiviral Signaling

Lunch and free time

Poster Session 3:
Cell Death and Disease

Cardiovascular Disease

Chair: Luca Scorrano

Derek Hausenloy (London, United Kingdom)

Keeping your mitochondria in shape to protect your heart

Fabio Di Lisa (Padua, Italy)

OPA1 and DRP1 in myocardial injury caused by ischemia/reperfusion

Frederic Joubert (Chatenay-Malabry, France)

Down-regulation of OPA1 alters mitochondrial morphology, PTP functioning, and cardiac adaptation to pressure overload in mice

Gerald Dorn (St. Louis, MO, USA)

Essential role of mitochondria fusion in cardiac embryonic development, postnatal growth, and adult homeostasis

Dinner and Gala evening

Breakfast

Metabolic Signaling and Disease

Chair: Anu Suomalainen-Wartiovaara

Nika Danial (Boston, MA, USA)

Metabolic fingerprints in molecular subtypes of diffuse large B-cell lymphoma

Orian Shirihai (Boston, MA, USA)

Mitochondrial dynamics in obesity and diabetes

Antonio Zorzano (Barcelona, Spain)

Mfn2 controls insulin signaling in muscle and liver and is essential for normal glucose homeostasis

Masatoshi Nomura (Fukuoka, Japan)

Role of Drp1 in pancreas β cells

David Ferrick (North Billerica, MA, USA)

Flux analyses with solid-state sensors to assess cellular bioenergetics in age-related diseases

Coffee break

Neurodegeneration

Chair: Elena Rugarli

Ruth Slack (Ottawa, Canada)

Mitochondrial dynamics in acute neuronal injury

Leo Pallanck (Seattle, WA, USA)

Using Drosophila to study the PINK1-Parkin Mitochondrial quality control pathway

Fredrik Sterky (Stockholm, Sweden)

Impaired supply of distal mitochondria in respiratory chain-deficient dopamine neurons in vivo

Richard Youle (Bethesda, MD, USA)

Damage Control - How the Pink1/Parkin pathway can regulate removal of impaired mitochondria by autophagy

Lunch and departure